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KMID : 0376419790030000301
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Chonbuk University Medical Journal
1979 Volume.3 No. 0 p.301 ~ p.306
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Study of Enzyme Activity on the Pathologic Tissues of Middle Ear.
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Abstract
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For the establishment of a better therapy for chronic otitis media, an exact knowledge of its pathogenesis is necessary. Among many kinds of the pathologic state of the chronic otitis media, cholesteatoma and chronic inflammation are very important because they may bring both intra and extra-cranial complications. Since the usual mechanism of cholesteatoma on bone can be explained by the mechanical or enzymatic theory, attempts were made to investigate the enzyme activities such as ATPase, phosphatases and transaminases in the cholesteatoma matrix and the pathologic granulation tissue in the middle ear cavity using the normal epithelial tissue taken from the post auricular region of the patients as control.
Results on this study were as follows.
1. Both the acid and alkaline phosphatase activities were much higher in the pathologic state than in normal epithelial skin, showing more than six times higher activities were found in case of acid phosphatase. It seemed to be very interesting finding that alkaline phosphatase activity was one hundred time higher in chronic inflammation and was twenty times higher in cholesteatoma than control.
2. ATPase activity was also increased 9 times and 7 times in the chronic inflammation and in the cholesteatoma respectively compared to that of control.
3. Glutamate oxaloacetate transaminase(GOT) activity was two times higher in the chronic inflammation than in control, while glutamate pyruvate tranaminase(GPT) showed nearly the same activity both in pathologic and normal tissues.
The further study of these results which show us much higher activity of ATPase and phosphatases in the pathologic state of the chror:ic otitis media than normal skin may bring us the good indication for the better understanding of the patcger.esis of this disorder in the biochemical aspect.
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